granulosa cell – stromal tumors: an immunohistochemical study including comparison of calretinin and inhibin

background and objective: histopathological evaluation of granulosa cell tumors (gct) of the ovary may be confused morphologically with a wide variety of the tumors. immunohistochemical staining for inhibin and calretinin can be used for better diagnosis. although it has been suggested that inhibin can be a sensitive marker for gct, it maybe had negative results in some cases.  in addition, caltrinin has been proposed as a marker for gct. the aim of this study was to investigate the immunohistochemical methods (ihc) including a comparison of calretinin and inhibin markers in the diagnosis of these tumors. patients and methods: this prospective study carried out from 2000 to 2009 at ghaem and omid hospitals, mashad university of medical sciences, iran. a total of 23 ovarian gct specimens were immunostained with commercially available antibodies to find out calretinin and inhibin immunoreactivity. data were analyzed by descriptive statistical method. a p value of =results: for diagnosing gct, the sensitivity of calretinin was 100% and that of the inhibin was almost 73.9%. the extent and severity of staining was more extensive for calretinin compared to inhibin pconclusion:  calretinin is a more sensitive biomarker for gct than inhibin.